The historic news comes just days after the Orlando massacre saw 49 people killed.
The Duke of Cambridge is to appear on the cover of gay magazine, Attitude – making him the first member of the royal family to pose for an LGBT publication.
Prince William – whose mother Diana was prominent HIV campaigner – posed for the cover after inviting the magazine to bring members of the LGBT community to Kensington Palace to hear their experiences of homophobic, bi-phobic and transphobic bullying, as well as the mental health implications it can have.
“No one should be bullied for their sexuality or any other reason and no one should have to put up with the kind of hate that these young people have endured in their lives,” he told Attitude after the meeting.
“The young gay, lesbian and transgender individuals I met through Attitude are truly brave to speak out and to give hope to people who are going through terrible bullying right now.
“Their sense of strength and optimism should give us all encouragement to stand up to bullying wherever we see it,” the Prince – who signed a book of condolence for the Orlando shooting victims with with his wife earlier this week – added.